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KMID : 0352519940310030377
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Korea Univercity Medical Journal
1994 Volume.31 No. 3 p.377 ~ p.392
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A Study of clinical response and Plasma Haolperidol, Reduced Haloperidol and
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Abstract
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Objective:
@EN The aim of this study was to examine the clinical response, the pharmacokinetic interaction of fluoxetine and haloperidol, and plasma 5-HIAA level changes after fluoxetine trial in haloperidol -stabilized schizophrencs.
@ES Methods:
@EN Fluoxetine was added for 6 weeks to stable doses of haloperidol given to 32 schizophrenic inpatients. The author checked PANSS, HRSD and Simpson -Angus Scale at baseline, 2nd week, 4th week and 6th week and measured plasma
haloperidol,
reduced haloperidol and 5 -HIAA level at baseline, 2nd week and 6th week of treatment.
@ES Results:
@EN 1) In total group, depressed symptoms and positive symptoms were improved, and extrapyramidal symptoms were worsened.
2) Plasma reduced haloperidol levels were increased continuously after fluoxeatine added, but plasma haloperidol levels were increased at 2nd week and were decreased at 6th week.
3) Plasma 5-HIAA levels were increased at 2nd week and were decreased at 6th week, although there were no significant changes on plasma 5-HEAA levels.
4) Between depressed group(baseline HRSD≥17) and nondepressed group (baseline (HRSD<17),
depressed symptoms were improved only in depressed group. decreased continuously after fluoxetine added, and there were significant changes between baseline and 6th.
5) Between depressed group and nondepressed group, plasma 5-HIAA levels were decreased continuously after fluoxetine added, and there were sgnificant changes between baseline and 6th week.
@ES Conclusions :
@EN Fluoxetine's effect on serotonin and indirect effect on dopamine, and increased plasma levels of haloperidol induced by fluoxetine may account for these findings.
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KEYWORD
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